Download PDF by C. Huang : Advanced Bariatric and Metabolic Surgery

By C. Huang

ISBN-10: 9533079266

ISBN-13: 9789533079264

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1993). I conclude that TGF1 is formed by the nonfat cells in human adipose tissue and acts as a local paracrine/autocrine factor that is required for the development of obesity and insulin resistance. However, this does not necessarily mean that it plays a causal role since it is a multifunctional regulator of cellular metabolism. , (2011) suggest that the inhibition of TGF1 release and/or action might have favorable effects on the development of insulin resistance in obesity by uncoupling respiration in white fat thus preventing fatty acid accumulation.

2010). , 2010). , 2011). Obesity effects on circulating OPG have been contradictory to say the least. , (2011) reported decreases in obesity. , (2010) concluded that there is no consensus on the relationship between BMI or other cardiovascular risk factors and the circulating levels of OPG much less the function of this protein in humans. 27 Plasminogen activator inhibitor protein-1 [PAI-1] PAI-1 is also known as serpin E1 and is a member of the serpin family of serine protease inhibitors. , 2007).

1999) originally reported that obesity is associated with elevated release of IL-6 by human adipose tissue and enhanced circulating levels of IL-6 and CRP. , (2004). There is virtually no synthesis of CRP by adipose tissue and the small amount of release seen in vitro could be due to release of CRP taken up from the circulation (Fain, 2006). CRP levels in humans correlate with those of serum amyloid (Larsson and Hansson, 2003) suggesting that both are inflammatory markers released by the liver in response to the low-grade inflammation induced by obesity.

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Advanced Bariatric and Metabolic Surgery by C. Huang


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