Airways Smooth Muscle: Modelling the Asthmatic Response In by Steve Webber, Jan-Anders Karlsson (auth.), Dr. David PDF

By Steve Webber, Jan-Anders Karlsson (auth.), Dr. David Raeburn, Dr. Mark A. Giembycz (eds.)

ISBN-10: 3034890001

ISBN-13: 9783034890007

ISBN-10: 3034898630

ISBN-13: 9783034898638

Building at the latest titles within the "Airways gentle Muscle" sub-series, the 6th quantity explores physiological and pharmacological tactics within the lung in vivo. a few of the animal versions on hand for learning the bronchospasm and irritation linked to human bronchial asthma are completely reviewed via across the world acknowledged scientists. particular chapters specialise in the issues of administering medicines to animal airlines, the mechanics of assessing lung functionality within the types, and describe intimately the species used, from rodents to primates. using genetically altered animals, a space of specific curiosity to molecular biologists, is additionally thought of extensive. This updated and greatly referenced paintings will turn out important to pharmacologists, physiologists and different organic scientists in any respect degrees in academia and within the pharmaceutical industry.

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Extra resources for Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo

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Since human bronchial airways are larger than those in small animals, turbulent fiow is more likely to occur. Further, small animals have a trachea that is much longer in relation to its diameter than is the human trachea (Figure 10). Thus, turbulence introduced by the larynx is less likely to persist into the bronchi in these species [4]. A number of studies have examined the regional deposition of inhaled particles in particular species. Making inter-species comparisons by comparing data from different studies is problematic since the characteristics of aerosols, delivery techniques and definitions of respiratory Human Guinea pig Figure 10.

70. Larsell 0, Dow RS. The innervation of the human lung. Am J Anat 1933; 52: 125-46. 71. Gaylor JB. The intrinsic nervous mechanism of the human lung. 1934; 57: 143-60. 72. Nadel JK, Cabezas GA, Austin JHM. In vivo roentgenographic examination of parasympathetic innervation of small airways. Use of powdered tantal um and a fine focal spot X-ray tube. Invest Radiol 1971; 6: 9-17. Airways Smooth Museie: Modelling the Asthmatic Response In Vivo ed. by D. Raeburn and M. A Giembycz © 1996 Birkhäuser Verlag Basel/Switzerland CHAPTER 2 Methods of Drug Administration to the Lung in Animals Stephen L.

Acute effect of inhaled isoproterenol on the mechanical characteristics of the lungs in normal man. J Clin Invest 1970; 49: 779-90. 37. Ayres SM, Griesbach SJ, Reimold F, Evans RG. Bronchial component in chronic obstructive lung disease. Am J Med 1974; 57: 183-91. 38. Colebatch HJH. The humoral regulation of alveolar ducts. In: Bouhuys A, editor. Airway dynamics, physiology and pharmacology. Springfield: CharIes C Thomas, 1970; 169-183. 39. Laitinen LA, Empey DW, Poppius H. Lernen RJ, Gold WM, Nadel JA.

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Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo by Steve Webber, Jan-Anders Karlsson (auth.), Dr. David Raeburn, Dr. Mark A. Giembycz (eds.)


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